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KMID : 1188320130070050560
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Gut and Liver
2013 Volume.7 No. 5 p.560 ~ p.568
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The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach
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Jo Hyun-Jin
Kim Na-Young
Nam Ryoung-Hee
Chang Hyun
Kim Joo-Hyon
Park Ji-Hyun
Kang Jung-Mook
Lee Dong-Ho
Jung Hyun-Chae
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Abstract
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Background/Aims:Cochinchina momordica seed extract (SK-MS10) has a gastric protective effect. We aimed to assess the effect of SK-MS10 on gastric acid secretion with morphologic changes in the aged rat.
Methods:Acid secretions were evaluated in the male F344 rats of four different ages (6-, 31-, 74-week, and 2-year). The 31-week-old rats were divided to three groups and continuously administered chow containing vehicle, SK-MS10 and lansoprazole, respectively. At the age of 74 weeks and 2 years, basal and stimulated acid was measured and the expression of mRNA and protein of H+-K+-ATPase were determined. The area of connective tissue of lamina propria was measured.
Results:Basal and stimulated gastric acid significantly decreased and connective tissue of lamina propria increased with age. The expression of mRNA and protein of H+-K+-ATPase significantly decreased with age. However, 74-week-old rats in the SK-MS10 group had higher stimulated gastric acid secretion than those in the vehicle and lansoprazole groups. In 2-year-old rats of SK-MS10 group, there was no increase of connective tissue.
Conclusions:As SK-MS10 kept the capacity of acid secretion as well as connective tissue area to comparable to young rats, it might valuable to perform further research regarding mechanism of SK-MS10 as an antiaging agent in the stomach.
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KEYWORD
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Gastric acid, Hydrogen-potassium-activated ATPase, Cochinchina momordica seed, Aging, Connective tissue
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